乙酰辅酶 A 羧化酶 β（ACACB）基因

乙酰辅酶 A 羧化酶 (ACC) 是一种复杂的多功能酶系统。 ACC 是一种含生物素的酶，可催化乙酰辅酶 A 羧化为丙二酰辅酶 A，这是脂肪酸合成中的限速步骤。 ACC-β 被认为通过丙二酰辅酶 A 抑制肉碱-棕榈酰-CoA 转移酶 I 的能力来控制脂肪酸氧化，这是线粒体摄取和氧化脂肪酸的限速步骤。 ACC-β 可能参与脂肪酸氧化的调节，而不是脂肪酸生物合成。[RefSeq 提供，2022 年 10 月]

Acetyl-CoA Carboxylase (ACC) is a complex multifunctional Enzyme system. ACC is a biotin-containing Enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. [provided by RefSeq, Oct 2022]